Alexander Disease
Alexander Disease 40
General: Rare degenerative neurologic disorder characterized by diffuse demyelination in the presence of Rosenthal fibers; cases may resemble multiple sclerosis; neuroradiologic findings include increased cerebellar white matter hyperintensity and diffuse periventricular signal hyperintensities.
Ocular: Impaired smooth pursuit; gaze-evoked horizontal nystagmus; slowed saccades; ocular myoclonus.
Clinical: In infants, hydrocephalus, spasticity, and seizures; in juveniles and adults, bulbar palsy and hyperreflexia, intermittent neurologic dysfunction.
Reichard EAP, Ball WS, Bove KE. Alexander disease: a case report and review of the literature. Pediatr Pathol Lab Med 1996; 16:327-343.
Russo LS, Aron A, Anderson PJ. Alexander's disease: a report and reappraisal. Neurology 1976; 26:607-614.
General: Rare degenerative neurologic disorder characterized by diffuse demyelination in the presence of Rosenthal fibers; cases may resemble multiple sclerosis; neuroradiologic findings include increased cerebellar white matter hyperintensity and diffuse periventricular signal hyperintensities.
Ocular: Impaired smooth pursuit; gaze-evoked horizontal nystagmus; slowed saccades; ocular myoclonus.
Clinical: In infants, hydrocephalus, spasticity, and seizures; in juveniles and adults, bulbar palsy and hyperreflexia, intermittent neurologic dysfunction.
Reichard EAP, Ball WS, Bove KE. Alexander disease: a case report and review of the literature. Pediatr Pathol Lab Med 1996; 16:327-343.
Russo LS, Aron A, Anderson PJ. Alexander's disease: a report and reappraisal. Neurology 1976; 26:607-614.
0 Comments:
Post a Comment
Links to this post:
Create a Link
<< Home