Eaton-Lambert Syndrome
Eaton-Lambert Syndrome (Myasthenic Syndrome; Ocular Myoclonus Syndrome; Myoclonic Syndrome)
General: Males; over 40 years of age; intrathoracic tumor; myasthenia-like condition less likely to have ocular manifestations; positive association with small cell cancer of the lung; underlying autoimmune basis.
Ocular: Decreased amplitude of version in all directions of gaze; ocular myoclonus; corneal abrasion; decreased corneal sensitivity; conjunctival injection; miotic pupil.
Clinical: Weakness; fatigue; peripheral paresthesia; dryness of mouth.
Cogan D. Myasthenia gravis. In: Albert DM, Jakobiec FA, eds. Principles and Practice of Ophthalmology, vol. V. Philadelphia: WB Saunders, 1994:2489.
Eaton LM, Lambert EM. Electromyography and electric stimulation of nerves in diseases of the motor units; observations on myasthenic syndrome associated with malignant tumors. J Am Med Assoc 1957; 163:1117.
Fetell MR, Younger DS. Neurologic paraneoplastic syndromes. In: Rowland LP, ed. Merritt’s Textbook of Neurology, 9th ed. Baltimore: Williams & Wilkins, 1995:935-936.
Geeraets WJ. Ocular Syndromes, 3rd ed. Philadelphia: Lea & Febiger, 1976.
Penn AS. Lambert-Eaton syndrome. In: Rowland LP, ed. Merritt’s Textbook of Neurology. 9th ed. Baltimore: Williams & Wilkins, 1995:761-763.
Sanders DB, Howard JF. Disorders of neuromuscular transmission. In: Bradley WG, et al. Neurology in Clinical practice. 2nd ed. Boston: Butterworth-Heinemann, 1995:1998-1999.
General: Males; over 40 years of age; intrathoracic tumor; myasthenia-like condition less likely to have ocular manifestations; positive association with small cell cancer of the lung; underlying autoimmune basis.
Ocular: Decreased amplitude of version in all directions of gaze; ocular myoclonus; corneal abrasion; decreased corneal sensitivity; conjunctival injection; miotic pupil.
Clinical: Weakness; fatigue; peripheral paresthesia; dryness of mouth.
Cogan D. Myasthenia gravis. In: Albert DM, Jakobiec FA, eds. Principles and Practice of Ophthalmology, vol. V. Philadelphia: WB Saunders, 1994:2489.
Eaton LM, Lambert EM. Electromyography and electric stimulation of nerves in diseases of the motor units; observations on myasthenic syndrome associated with malignant tumors. J Am Med Assoc 1957; 163:1117.
Fetell MR, Younger DS. Neurologic paraneoplastic syndromes. In: Rowland LP, ed. Merritt’s Textbook of Neurology, 9th ed. Baltimore: Williams & Wilkins, 1995:935-936.
Geeraets WJ. Ocular Syndromes, 3rd ed. Philadelphia: Lea & Febiger, 1976.
Penn AS. Lambert-Eaton syndrome. In: Rowland LP, ed. Merritt’s Textbook of Neurology. 9th ed. Baltimore: Williams & Wilkins, 1995:761-763.
Sanders DB, Howard JF. Disorders of neuromuscular transmission. In: Bradley WG, et al. Neurology in Clinical practice. 2nd ed. Boston: Butterworth-Heinemann, 1995:1998-1999.
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