Glossary and Index 150
Linoleic acid: One of the essential omega-6 fatty acids. Found in vegetable oils and animal fat. The western diet is thought to contain too much linoleic acid and too high a ratio of linoleic (omega-6) to linoleic (omega-3) fatty acids. AMD patients should reduce consumption of linoleic acid; 46.
Lucentis®: Generic name is ranibizumab. An antibody to vascular endothelial growth factor that has been proven to reduce vision loss and even to increase vision in patients with neovascular AMD; 70.
Lutein: A carotenoid found in high quantities in the macula; 43.
Macugen®: Generic name is pegaptanib. A molecule that inhibits one form of vascular endothelial growth factor. Has been found to reduce vision loss, when compared to no treatment, in patients with the neovascular form of AMD; 69.
Macula: The central part of the retina that allows for detailed vision; 3.
Macular Photocoagulation Study (MPS): A series of randomized controlled trials that proved thermal laser preserved vision in patients with the wet form of AMD; 17.
Macular translocation: A surgery during which the retina is detached and moved to an area of RPE not involved with new blood vessels as a treatment for neovascular AMD. There are two types:
a. Limited macular translocation – the retina is not cut but detached and pushed inferiorly with a gas bubble; 80.
b. Three hundred and sixty degree translocation – the retina is cut at the periphery and the retina is rotated to a new position; 81.
MARINA: The acronym for the Minimally classic/occult trial of the Anti-VEGF antibody Ranibizumab In the treatment of Neovascular AMD. This was the trial in which ranibizumab (Lucentis®) improved the vision at one-year in patients with the wet form of AMD compared to patients who had received sham injections; 71.
Lucentis®: Generic name is ranibizumab. An antibody to vascular endothelial growth factor that has been proven to reduce vision loss and even to increase vision in patients with neovascular AMD; 70.
Lutein: A carotenoid found in high quantities in the macula; 43.
Macugen®: Generic name is pegaptanib. A molecule that inhibits one form of vascular endothelial growth factor. Has been found to reduce vision loss, when compared to no treatment, in patients with the neovascular form of AMD; 69.
Macula: The central part of the retina that allows for detailed vision; 3.
Macular Photocoagulation Study (MPS): A series of randomized controlled trials that proved thermal laser preserved vision in patients with the wet form of AMD; 17.
Macular translocation: A surgery during which the retina is detached and moved to an area of RPE not involved with new blood vessels as a treatment for neovascular AMD. There are two types:
a. Limited macular translocation – the retina is not cut but detached and pushed inferiorly with a gas bubble; 80.
b. Three hundred and sixty degree translocation – the retina is cut at the periphery and the retina is rotated to a new position; 81.
MARINA: The acronym for the Minimally classic/occult trial of the Anti-VEGF antibody Ranibizumab In the treatment of Neovascular AMD. This was the trial in which ranibizumab (Lucentis®) improved the vision at one-year in patients with the wet form of AMD compared to patients who had received sham injections; 71.
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